2-Aminothiazole → HCID 59732938、化合物

HRID 131928

反応式

HRID 131928 の反応式
NC1C=C(C)C=CC=1[C:4](O)=[O:5].[NH2:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[O:28][CH3:29])=[O:21].[NH2:30][C:31]1[S:32][CH:33]=[CH:34][N:35]=1>>[NH2:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[O:28][CH3:29])=[O:21].[CH3:29][O:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[C:20]([C:14]1[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=1[NH:12][C:4]([NH:30][C:31]1[S:32][CH:33]=[CH:34][N:35]=1)=[O:5])=[O:21]

参加物

5

反応物 3

HCID 21552-AminothiazoleHCID 753164-Methylanthranilic acidHCID 66998866(2-Amino-4-methyl-phenyl)-(2-methoxy-phenyl)-methanone

生成物 2

HCID 59732938HCID 59732938、化合物収率 70%HCID 66998866(2-Amino-4-methyl-phenyl)-(2-methoxy-phenyl)-methanone収率 30%

実験手順

(2-Amino-4-methyl-phenyl)-(2-methoxy-phenyl)-methanone (723 g, 30%) was prepared from 2-amino-4-methyl-benzoic acid (1.51 g, 10 mmol) following the general procedure S. 1-[2-(2-methoxy-benzoyl)-5-methyl-phenyl]-3-thiazol-2-yl-urea (129 mg, 70%) was prepared from (2-amino-4-methyl-phenyl)-(2-methoxy-phenyl)-methanone (121 mg, 0.5 mmol) and 2-aminothiazole (0.060 g, 0.6 mmol) following the general procedure D.

出典と根拠

ORDレコード
ord-ade1a85adb924061b6e835d2696efdc5
出典データセット
uspto-grants-2008_06
特許番号
US07384967B2

関連ノート

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