化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 2-[4-Fluoro-2-(3-thiazol-2-yl-ureido)-phenoxy]-6-methoxybenzoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| 反応物 | Methyl 2-hydroxy-6-methoxybenzoate | HCID 527092 | — |
| 反応物 | 2-(2-Amino-4-fluoro-phenoxy)-6-methoxy-benzoic acid methyl ester | HCID 66999207 | — |
| 生成物 | 2-[4-Fluoro-2-(3-thiazol-2-yl-ureido)-phenoxy]-6-methoxybenzoic acid methyl ester | HCID 59732977 | 62% |
| 生成物 | 2-(4-Fluoro-2-nitro-phenoxy)-6-methoxy-benzoic acid methyl ester | HCID 66998457 | 58% |
反応手順
2-(4-Fluoro-2-nitro-phenoxy)-6-methoxy-benzoic acid methyl ester (0.94 g, 58%) was prepared from 2-hydroxy-6-methoxy-benzoic acid methyl ester (1.01 g, 5.5 mmol) and 2,5-difluoro-1-nitro-benzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2-amino-4-fluoro-phenoxy)-6-methoxy-benzoic acid methyl ester (0.51 g, 60%) following general procedure C. 2-[4-Fluoro-2-(3-thiazol-2-yl-ureido)-phenoxy]-6-methoxy-benzoic acid methyl ester (129 mg, 62%) was prepared from 2-(2-amino-4-fluoro-phenoxy)-6-methoxy-benzoic acid methyl ester (145 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-1df2ed88113b4e57b40f8bf0d3cff228 |
| 出典メモ | uspto-grants-2008_06 |