化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 3-Cyclopentylmethoxy-4-nitrotoluene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| 反応物 | Cyclopentanemethanol | HCID 77195 | — |
| 反応物 | 2-(Cyclopentylmethoxy)-4-methylaniline | HCID 26189518 | — |
| 生成物 | 1-(2-Cyclopentylmethoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea | HCID 59732830 | 68% |
| 生成物 | 3-Cyclopentylmethoxy-4-nitrotoluene | HCID 66998981 | 70% |
反応手順
3-Cyclopentylmethoxy-4-nitrotoluene (0.82 g, 70%) was prepared from cyclopentylmethanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 2-cyclopentylmethoxy-4-methyl-aniline (0.58 g, 81%) following general procedure C. 1-(2-Cyclopentylmethoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea (225 mg, 68%) was prepared from 2-cyclopentylmethoxy-4-methyl-aniline (205 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-ef15e105545f4a25a74632b1ecfcafea |
| 出典メモ | uspto-grants-2008_06 |