2-Aminothiazole → 1-[2-(2-Fluoro-6-methoxy-phenoxy)-4-methyl-phenyl]-3-thiazol-2-yl-urea

HRID 131971

反応式

HRID 131971 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[OH:10].F[C:12]1[CH:13]=[C:14](C)[CH:15]=[CH:16][C:17]=1[N+:18]([O-:20])=[O:19].F[C:23]1C=CC(N)=[C:25]([O:30]C2C(OC)=CC=CC=2F)C=1.[F:40][C:41]1[CH:55]=[CH:54][CH:53]=[C:52]([O:56][CH3:57])[C:42]=1[O:43][C:44]1[CH:50]=[C:49]([CH3:51])[CH:48]=[CH:47][C:45]=1[NH2:46].[NH2:58][C:59]1[S:60][CH:61]=[CH:62][N:63]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[O:10][C:16]1[C:17]([N+:18]([O-:20])=[O:19])=[C:12]([CH3:23])[CH:13]=[CH:14][CH:15]=1.[F:40][C:41]1[CH:55]=[CH:54][CH:53]=[C:52]([O:56][CH3:57])[C:42]=1[O:43][C:44]1[CH:50]=[C:49]([CH3:51])[CH:48]=[CH:47][C:45]=1[NH:46][C:25]([NH:58][C:59]1[S:60][CH:61]=[CH:62][N:63]=1)=[O:30]

参加物

7

反応物 5

HCID 21552-AminothiazoleHCID 67966Benzene, 2-fluoro-4-methyl-1-nitro-HCID 27373672-Fluoro-6-methoxyphenolHCID 669988784-Fluoro-2-(2-fluoro-6-methoxyphenoxy)anilineHCID 66999002HCID 66999002、化合物

生成物 2

HCID 597328051-[2-(2-Fluoro-6-methoxy-phenoxy)-4-methyl-phenyl]-3-thiazol-2-yl-urea収率 65%HCID 669990333-(2-Fluoro-6-methoxyphenoxy)-nitrotoluene収率 65%

実験手順

3-(2-fluoro-6-methoxyphenoxy)-nitrotoluene (0.9 g, 65%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure A. This compound was reduced to 4-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (0.58 g, 72%) following the general procedure C. 1-[2-(2-Fluoro-6-methoxy-phenoxy)-4-methyl-phenyl]-3-thiazol-2-yl-urea (122 mg, 65%) was prepared from 2-(2-fluoro-6-methoxy-phenoxy)-4-methyl-aniline (124 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

出典と根拠

ORDレコード
ord-cfe5d715c8bf4f098de9cc1181544d90
出典データセット
uspto-grants-2008_06
特許番号
US07384967B2

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