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2-Aminothiazole → 4-(2-Fluoro-6-methoxy-phenoxy)-3-nitrobenzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 4-Fluoro-3-nitrobenzaldehyde | HCID 598129 | — |
| 反応物 | 2-Fluoro-6-methoxyphenol | HCID 2737367 | — |
| 反応物 | 5-Formyl-2-(2-fluoro-6-methoxy-phenoxy)-aniline | HCID 86593084 | — |
| 生成物 | 1-[2-(2-Fluoro-6-methoxy-phenoxy)-5-formyl-phenyl]-3-thiazol-2-yl-urea | HCID 59732954 | 69% |
| 生成物 | 4-(2-Fluoro-6-methoxy-phenoxy)-3-nitrobenzaldehyde | HCID 86593083 | 70% |
反応手順
4-(2-Fluoro-6-methoxy-phenoxy)-3-nitrobenzaldehyde (1.0 g, 70%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 4-fluoro-3-nitrobenzaldehyde (0.84 g, 5.0 mmol) following the general procedure A. This was reduced to 5-formyl-2-(2-fluoro-6-methoxy-phenoxy)-aniline (0.57 g, 62%) following general procedure B. 1-[2-(2-Fluoro-6-methoxy-phenoxy)-5-formyl-phenyl]-3-thiazol-2-yl-urea (265 mg, 69%) was prepared from 5-formyl-2-(2-fluoro-6-methoxy-phenoxy)-aniline (261 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-971efa14457b47c499e8f06cd1911d93 |
| 出典メモ | uspto-grants-2008_06 |