化工社化工社 化学情報印刷レポート · 研究参考用
Ethanolamine → (S)-N-{3-Cyclohexyl-1-[2-(5-benzyloxy-2,3-dihydro-indol-1-yl)-ethylcarbamoyl]-propyl}-3-methoxy-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | m-Anisoyl chloride | HCID 74374 | — |
| 反応物 | 5-(Benzyloxy)-2,3-dihydro-1H-indole | HCID 16794881 | — |
| 反応物 | (S)-2-amino-4-cyclohexylbutanoic acid | HCID 22839041 | — |
| 生成物 | (S)-N-{3-Cyclohexyl-1-[2-(5-benzyloxy-2,3-dihydro-indol-1-yl)-ethylcarbamoyl]-propyl}-3-methoxy-benzamide | HCID 11444487 | 10% |
反応手順
Following the procedures of Example 3, except using m-anisoyl chloride, (S)-2-amino-4-cyclohexyl-butyric acid, ethanolamine and 5-benzyloxyindoline as starting materials, the title compound was prepared in 10% yield. The final material was purified by reverse phase preparative HPLC using TFA as a modifier. The final compound is therefore a partial TFA salt: HPLC-MS calcd. for C35H43N3O4 (M+H+) 570.3, found 570.6.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384970B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-b7d77f068c1441a08b4c05fbe9673a44 |
| 出典メモ | uspto-grants-2008_06 |