関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Formic Acid | HCID 284 | — |
| 反応物 | Benzylamine | HCID 7504 | — |
| 反応物 | Epichlorohydrin | HCID 7835 | — |
| 反応物 | N,N-Dimethyl-1,3-propanediamine | HCID 7993 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Epichlorohydrin dimethylaminopropylamine benzylamine | HCID 131728152 | — |
反応手順
1 020 g (10 mol) of dimethylaminopropylamine and 267.5 g (2.5 mol) of benzylamine are mixed in 1 519.1 g of water. The solution/suspension is heated to 50° C. Thereafter, 931 ml of epichlorohydrin (1 098.4 g/l 1.875 mol) are added dropwise at a rate of 16 ml/min while heating to 85° C., and stirring is effected for two hours at 85° C. The stirring at 85° C. is continued until free alkylating agent is no longer detectable (Preuβmann test). The reaction mixture is cooled, diluted with 2 l of water and brought to a pH of 7.0 with 85% strength formic acid. Further water is added until the solids content is 21%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07728072B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-4d438631632e491eab1ba9bb43893932 |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
