Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1325795ノート

反応式

HRID 1325795 の反応式
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>C1=[CH]2->[Ni]3(<-[CH](=CCC2)CC1)<-[CH]1=CCC[CH]->3=CCC1.CC(C)n1cc[n+](C(C)C)c1.COCCOCCOC.CS(C)=O.C[Si](C)(C)[N-][Si](C)(C)C.[Cl-].[Li+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

参加物

10

反応物 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

生成物 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholine収率 9.74%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholine収率 0%

試薬・触媒・溶媒 5

HCID 2733832Lithium Hexamethyldisilazide試薬HCID 112292421,3-Diisopropylimidazolium chloride触媒HCID 178420723HCID 178420723、化合物触媒HCID 679Dimethyl Sulfoxide溶媒5 回HCID 8150Diglyme溶媒5 回

反応条件

温度
60 °C

後処理

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 相を保持
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

出典と根拠

ORDレコード
ord-1be4b197952d45c2a6bacec0c455590b
出典データセット
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
元リンク
出典を表示

反応ノート

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