反応式
[Br:1][C:2]1[N:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([O:18][CH2:19][CH3:20])([CH3:17])[CH3:16])[C:5]([NH2:21])=[CH:4][CH:3]=1.[F:22][C:23]([F:35])([F:34])[O:24][C:25]1[CH:30]=[CH:29][C:28]([N:31]=[C:32]=[O:33])=[CH:27][CH:26]=1>>[Br:1][C:2]1[N:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([O:18][CH2:19][CH3:20])([CH3:17])[CH3:16])[C:5]([NH:21][C:32]([NH:31][C:28]2[CH:29]=[CH:30][C:25]([O:24][C:23]([F:22])([F:34])[F:35])=[CH:26][CH:27]=2)=[O:33])=[CH:4][CH:3]=1参加物
3
実験手順
Example 582 was prepared from 6-bromo-2-(2-(2-ethoxypropan-2-yl)phenoxy)pyridin-3-amine and p-trifluoromethoxyphenyl isocyanate according to the procedure described for Example 2. (M−EtO)=508, 510. 1H NMR (400 MHz, DMSO-d6) δppm 0.82 (t, J=7.0 Hz, 3H), 1.53 (s, 6H), 3.21 (q, J=7.0 Hz, 2H), 7.21 (dd, J=8.1, 1.3 Hz, 1H), 7.30 (m, 6H), 7.56 (m, 4H), 8.49 (d, J=8.4 Hz, 1H), 8.73 (s, 1H), 9.61 (s, 1H).
出典と根拠
- ORDレコード
- ord-8f7f31758e064d5584f15af0eca82a91
- 出典データセット
- uspto-grants-2008_06
- 特許番号
- US07388021B2
関連ノート
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