3-Bromobenzonitrile → 3-(6-(1-Acetyl-pyrrolidin-2-yl)-2-pyridin-2-yl-1H-benzimidazol-5-yloxy)-benzonitrile

HRID 13269

反応式

HRID 13269 の反応式
[OH:1][C:2]1[C:3]([CH:25]2[CH2:29][CH2:28][CH2:27][N:26]2[C:30](=[O:32])[CH3:31])=[CH:4][C:5]2[N:9](COCC[Si](C)(C)C)[C:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[N:7][C:6]=2[CH:24]=1.[C:33]([C:35]1[CH:36]=[C:37](Br)[CH:38]=[CH:39][CH:40]=1)#[N:34]>>[C:30]([N:26]1[CH2:27][CH2:28][CH2:29][CH:25]1[C:3]1[C:2]([O:1][C:39]2[CH:40]=[C:35]([CH:36]=[CH:37][CH:38]=2)[C:33]#[N:34])=[CH:24][C:6]2[N:7]=[C:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[NH:9][C:5]=2[CH:4]=1)(=[O:32])[CH3:31]

参加物

3

実験手順

The entitled compound was obtained as an oily substance in the same method as in Example 121 (step 11), (step 12) or in accordance with the method or by combining it with an ordinary method but using 1-(2-(6-hydroxy-2-pyridin-2-yl-3-(2-trimethylsilanyl-ethoxymethyl)-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanone obtained in Example 121 (step 10) and 3-cyanobromobenzene.

後処理

  1. customThe entitled compound was obtained as an oily substance in the same method as in Example 121 (step 11), (step 12) or in accordance with the method

出典と根拠

ORDレコード
ord-34f455e98852447aadb9e7dea234af3f
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

関連ノート

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