化工社化工社 化学情報印刷レポート · 研究参考用
tert-Butanol → 3-azido-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-propanoic acid, ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butanol | HCID 6386 | — |
| 反応物 | Ethyl Acrylate | HCID 8821 | — |
| 反応物 | Potassium | HCID 5462222 | — |
| 反応物 | 3-Azido-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one | HCID 10932520 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Tert-butanol tetrahydrofuran | HCID 66775918 | — |
| 生成物 | 3-azido-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-propanoic acid, ethyl ester | HCID 86749790 | — |
反応手順
A solution of 3-azido-1,3,4,5-tetrahydro-2H-1-benzazepine-2-one [prepared as described by Watthey et al., J. Med. Chem., 28, p. 1511-15156 (1985)] in tetrahydrofuran/tert-butanol was cooled to 0° C. and treated with ethyl acrylate and 1N tert-butanol, potassium salt/tetrahydrofuran according to the procedure of Example 40 part (a) affording 3-azido-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-propanoic acid, ethyl ester as a syrup. TLC (ethyl ether:hexane, 1:1) Rf =0.45.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723602 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-75d6830239304b61acc836550d1f3a66 |
| 出典メモ | uspto-grants-1998_03 |