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Methyl iodide → 4-Methylheptane-3,5-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3,5-Heptanedione | HCID 81923 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Methylheptane-3,5-dione | HCID 3013982 | 94% |
反応手順
To 0.02 mol sodium hydride was added 100 ml anhydrous tetrahydrofuran, slowly added dropwise 0.02 mol 3,5-heptandione at room temperature. Upon completion, the mixture was stirred for 0.5 hours, then 0.04 mol iodomethane was slowly added dropwise. After stirred at room temperature for 10 hours, 20 ml water was added. White solid was precipitated. The solid was filtered, washed with water, and dried to give 4-methyl-3,5-heptandione as a white solid, and the yield was 94%. m.p. was 91-92° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07388061B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-215ad9bed3a34087a85ae1671f74959f |
| 出典メモ | uspto-grants-2008_06 |