Methyl iodide → 4-Methylheptane-3,5-dione

HRID 132721

反応式

HRID 132721 の反応式
[H-].[Na+].O1CCC[CH2:4]1.[CH3:8][CH2:9][C:10](=[O:16])[CH2:11][C:12](=[O:15])[CH2:13][CH3:14].IC>O>[CH3:4][CH:11]([C:10](=[O:16])[CH2:9][CH3:8])[C:12](=[O:15])[CH2:13][CH3:14]

参加物

6

反応物 4

HCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 819233,5-Heptanedione

生成物 1

HCID 30139824-Methylheptane-3,5-dione収率 94%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 0.02 mol sodium hydride was added 100 ml anhydrous tetrahydrofuran, slowly added dropwise 0.02 mol 3,5-heptandione at room temperature. Upon completion, the mixture was stirred for 0.5 hours, then 0.04 mol iodomethane was slowly added dropwise. After stirred at room temperature for 10 hours, 20 ml water was added. White solid was precipitated. The solid was filtered, washed with water, and dried to give 4-methyl-3,5-heptandione as a white solid, and the yield was 94%. m.p. was 91-92° C.

後処理

  1. stirringAfter stirred at room temperature for 10 hours
  2. customWhite solid was precipitated
  3. filtrationThe solid was filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-215ad9bed3a34087a85ae1671f74959f
出典データセット
uspto-grants-2008_06
特許番号
US07388061B2

関連ノート

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