Benzyl Bromide → 50984-08-2

HRID 132763ノート

反応式

HRID 132763 の反応式
C(=O)([O-])[O-].[K+].[K+].[O:7]=[C:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]([O:15][CH2:16][CH3:17])=[O:14].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CC(C)=O>[CH2:18]([C:9]1([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:10][CH2:11][CH2:12][C:8]1=[O:7])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 69136Ethyl 2-oxocyclopentanecarboxylate

生成物 1

HCID 26669250984-08-2収率 66.9%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

38.7 grams of anhydrous potassium carbonate and 90 ml of acetone were mixed, then with stirring, to the resulting mixture was dropwise added a solution of 10.4 ml of ethyl 2-oxocyclopentane carboxylate in 45 ml of acetone. After stirring at room temperature for 35 minutes, 16.7 ml of benzyl bromide was dropwise added thereto, and the reaction was allowed to continue under reflux for 3 hours. Then the reaction mixture was cooled to room temperature, filtered, concentrated, and distilled under reduced pressure. 11.54 g of colorless liquid as the second distillate cut was collected. Yield: 66.9%.

後処理

  1. stirringAfter stirring at room temperature for 35 minutes
  2. temperatureunder reflux for 3 hours
  3. filtrationfiltered
  4. concentrationconcentrated
  5. distillationdistilled under reduced pressure
  6. distillation11.54 g of colorless liquid as the second distillate cut was collected

出典と根拠

ORDレコード
ord-e1d746ce33cf4926a7b7bfb2c0476103
出典データセット
uspto-grants-2008_06
特許番号
US07388103B2

反応ノート

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