Ammonia → (1S)-2-amino-1-[(4r)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

HRID 132802ノート

反応式

HRID 132802 の反応式
[CH2:1](O)[C@@H:2]([OH:11])[C@H:3]1[O:8][C:6](=O)[C:5](O)=[C:4]1[OH:10].[NH3:13].[CH3:14]O>>[NH2:13][CH2:1][C@@H:2]([C@H:3]1[CH2:4][O:10][C:6]([CH3:5])([CH3:14])[O:8]1)[OH:11]

参加物

4

反応物 3

HCID 222AmmoniaHCID 887Methanol2 回HCID 54675810Erythorbic Acid

生成物 1

HCID 59734745(1S)-2-amino-1-[(4r)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

実験手順

Epoxide 22 was prepared (Y. L. Merrer et al., Tetrahed. Lett. 1988, 31, 1003; M. Pottie et al. 1991, 2, 329; A. H. Al-Hakim et al., Synthesis, 1985, 207) from inexpensive and enantiomerically pure D-isoascorbic acid. The epoxide was dissolved in a large excess of methanol and added to a large volume of a saturated solution of ammonia in methanol and allowed to stand for 24 hr. The solvent was evaporated to afford the aminoalcohol 23.

後処理

  1. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-b3b638a5e35343ec8a409e8a6450f4bd
出典データセット
uspto-grants-2008_06
特許番号
US07388118B2

反応ノート

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