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(5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanone → {5-[3-(3-Aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1H-indol-2-yl}-morpholin-4-yl-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanone | HCID 44185244 | — |
| 反応物 | 3-(3-Azabicyclo[3.1.0]hexan-3-yl)propan-1-ol | HCID 67527519 | — |
| 生成物 | {5-[3-(3-Aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1H-indol-2-yl}-morpholin-4-yl-methanone | HCID 16754253 | — |
反応手順
In analogy to the procedure described for the synthesis of example 1, step 1, the title compound was synthesized from (5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanone (example 5, step 3) and 3-(3-aza-bicyclo[3.1.0]hex-3-yl)-propan-1-ol (example 5, step 2). The title product was obtained in 49% yield as white solid. MS (m/e): 370.5 (MH+, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07388095B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-3e3303021aa14bd39e263710560930e2 |
| 出典メモ | uspto-grants-2008_06 |