Hydrochloric Acid → 2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,7-naphthyridine hydrochloride
反応式
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:12]=[CH:11][C:10]2[CH2:9][CH2:8][N:7](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH2:6][C:5]=2[N:4]=1.[ClH:34]>CO.O1CCOCC1>[ClH:34].[F:33][C:2]([F:1])([F:32])[C:3]1[CH:12]=[CH:11][C:10]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=2[N:4]=1参加物
5
実験手順
A solution of the product (94 mg, 0.20 mmol) from Step A above in 0.5 mL of methanol and 2.0 mL of 4.0M hydrogen chloride in 1,4-dioxane was kept at room temperature for 18 h. The reaction mixture was concentrated under a stream of nitrogen, and the residue was triturated with ether. The resultant precipitate was collected and dried in vacuo to afford the title compound as a pale yellow powder. LC/MS 203.1 (M+1).
後処理
- concentrationThe reaction mixture was concentrated under a stream of nitrogen
- customthe residue was triturated with ether
- customThe resultant precipitate was collected
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-44344492684445e19e5b1c9b21bc7878
- 出典データセット
- uspto-grants-2008_06
- 特許番号
- US07388019B2
反応ノート
読み込み中…