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HRID 132863作成日：2026年10月26日

Ethanimidamide, acetate (1:1) → tert-Butyl 2-methyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

https://huagongshe.com/reaction/132863

反応式

関与物質

役割名称HCID仕込み量
反応物Ethanimidamide, acetate (1:1)HCID 160356—
反応物tert-butyl 3-[(dimethylamino)methylene]-4-oxotetrahydro-1(2H)-pyridinecarboxylateHCID 53395404—
生成物tert-Butyl 2-methyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylateHCID 69223447—

反応手順

Reaction of tert-butyl 4-oxo-3-(dimethylaminomethylidene)-1-piperidinecarboxylate (1.15 g) from Intermediate 28, Step A with acetamidine acetate (0.54 g) according to the procedure described for Intermediate 28, Step B, and purification by flash chromatography (silica gel; 2% methanol/dichloromethane as eluant) afforded the title compound as a viscous orange oil.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07388019B2
出典データセットuspto-grants-2008_06
ORD IDord-f99acf8cfdd64b2a8b8c1ee5cdb403f7
出典メモuspto-grants-2008_06