1H-Pyrazole-3-carbaldehyde → HCID 178504806、化合物

HRID 13297

反応式

HRID 13297 の反応式
[NH:1]1[CH:5]=[CH:4][C:3]([CH:6]=O)=[N:2]1.[F:8][C:9]1[CH:34]=[CH:33][CH:32]=[CH:31][C:10]=1[O:11][C:12]1[CH:13]=[C:14]([NH2:30])[C:15]([NH2:29])=[CH:16][C:17]=1[O:18][C:19]1[CH:20]=[N:21][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:23][CH:24]=1>CN(C)C=O>[F:8][C:9]1[CH:34]=[CH:33][CH:32]=[CH:31][C:10]=1[O:11][C:12]1[C:17]([O:18][C:19]2[CH:20]=[N:21][C:22]([S:25]([CH3:28])(=[O:26])=[O:27])=[CH:23][CH:24]=2)=[CH:16][C:15]2[NH:29][C:6]([C:3]3[CH:4]=[CH:5][NH:1][N:2]=3)=[N:30][C:14]=2[CH:13]=1

参加物

4

反応物 2

HCID 122183831H-Pyrazole-3-carbaldehydeHCID 231451984-(2-Fluoro-phenoxy)-5-(6-methanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine

生成物 1

HCID 178504806HCID 178504806、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
90 °C

実験手順

3.9 mg of 1H-pyrazole-3-carboxaldehyde was added to a dimethylformamide (0.5 ml) solution of 15 mg of 4-(2-fluoro-phenoxy)-5-(6-methanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 200, and the reaction liquid was stirred at 90° C. for 30 minutes. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=9/1) to obtain the entitled compound as a white solid.

後処理

  1. customthe reaction liquid
  2. customThe solvent was evaporated away under reduced pressure
  3. customthe resulting residue was purified
  4. customthrough partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=9/1)

出典と根拠

ORDレコード
ord-81e989125268424bbc0e347d964253ac
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

関連ノート

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