(5-Hydroxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-1-yl)methyl acetate → (5-Oxo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-1-yl)methyl acetate

HRID 132989

反応式

HRID 132989 の反応式
[C:1]([O:4][CH2:5][C:6]1[C:16]2[CH2:15][CH2:14][C:13]3[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=3[CH:11]([OH:21])[C:10]=2[CH:9]=[CH:8][CH:7]=1)(=[O:3])[CH3:2]>ClCCl.[O-2].[O-2].[Mn+4]>[C:1]([O:4][CH2:5][C:6]1[C:16]2[CH2:15][CH2:14][C:13]3[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=3[C:11](=[O:21])[C:10]=2[CH:9]=[CH:8][CH:7]=1)(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 58646846(5-Hydroxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-1-yl)methyl acetate

生成物 1

HCID 58646841(5-Oxo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-1-yl)methyl acetate収率 77.7%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

3.5 g of (5-hydroxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-1-yl)methyl acetate prepared in Example 1-d was dissolved in 50 ml of dichloromethane and 10 g of manganese dioxide was added, followed by stirring at room temperature for 2 days. The reaction mixture was filtered through Celite, and the filtrate was washed with ethyl acetate and the solvent was evaporated, to give 2.7 g of the title compound as a colorless oil.

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. washthe filtrate was washed with ethyl acetate
  3. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-ec317ec2af7e4e39a6a57247c64c0535
出典データセット
uspto-grants-2008_06
特許番号
US07390797B2

関連ノート

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