Methyl pyrazine-2-carboximidate → 5-(2-Cyano-phenoxy)-2-pyrazin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

HRID 13309ノート

反応式

HRID 13309 の反応式
[C:1]([C:3]1[CH:29]=[CH:28][CH:27]=[CH:26][C:4]=1[O:5][C:6]1[CH:7]=[C:8]([NH2:25])[C:9]([NH2:24])=[CH:10][C:11]=1[O:12][C:13]1[CH:14]=[N:15][C:16]([S:19]([CH2:22][CH3:23])(=[O:21])=[O:20])=[CH:17][CH:18]=1)#[N:2].CO[C:32]([C:34]1[CH:39]=[N:38][CH:37]=[CH:36][N:35]=1)=N>>[C:1]([C:3]1[CH:29]=[CH:28][CH:27]=[CH:26][C:4]=1[O:5][C:6]1[C:11]([O:12][C:13]2[CH:14]=[N:15][C:16]([S:19]([CH2:22][CH3:23])(=[O:20])=[O:21])=[CH:17][CH:18]=2)=[CH:10][C:9]2[NH:24][C:32]([C:34]3[CH:39]=[N:38][CH:37]=[CH:36][N:35]=3)=[N:25][C:8]=2[CH:7]=1)#[N:2]

参加物

3

反応物 2

HCID 470894Methyl pyrazine-2-carboximidateHCID 23145557HCID 23145557、化合物

生成物 1

HCID 231452665-(2-Cyano-phenoxy)-2-pyrazin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

実験手順

The entitled compound was obtained as a brown solid in the same method as in Example 205 or in accordance with the method or by combining it with an ordinary method but using 4-(2-cyano-phenoxy)-5-(6-ethanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 221 (step 3) and methylpyrazin-2-imidate.

後処理

  1. customThe entitled compound was obtained as a brown solid in the same method as in Example 205 or in accordance with the method

出典と根拠

ORDレコード
ord-2e7a29f35a76457ca080abe9f57c88be
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

反応ノート

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