Ammonia → 2-Amino-3-nitro-8-methylquinoline
反応式
Cl[C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:9]2[C:4](=[C:5]([CH3:15])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH3:16]>>[NH2:16][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:9]2[C:4](=[C:5]([CH3:15])[CH:6]=[CH:7][CH:8]=2)[N:3]=1参加物
3
反応条件
- 温度
- 130 °C
実験手順
1.6 g of 2-chloro-8-methyl-3-nitroquinoline (compound C1) is dissolved in 70 ml of ethanolic ammonia solution and stirred at 130° C. for 18 h in an autocave. After cooling to room temperature, the reaction mixture is concentrated in vacuo and the residue recrystallized from ethyl acetate. 1.2 g of the title compound are obtained as red solid.
後処理
- temperatureAfter cooling to room temperature
- concentrationthe reaction mixture is concentrated in vacuo
- customthe residue recrystallized from ethyl acetate
出典と根拠
- ORDレコード
- ord-8138eba8947d4b7c8a83e99ea616d2eb
- 出典データセット
- uspto-grants-2008_06
- 特許番号
- US07390819B2
反応ノート
読み込み中…