Acetic Anhydride → N,5-Dimethyl-1H-indol-2-amine dihydrochloride

HRID 133171

反応式

HRID 133171 の反応式
[ClH:1].[CH3:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9]N)=[CH:5][CH:4]=1.[CH2:11]([N:13](CC)[CH2:14]C)[CH3:12].C(OC(=O)C)(=O)C>O.CCOCC>[ClH:1].[ClH:1].[CH3:14][NH:13][C:11]1[NH:9][C:6]2[C:7]([CH:12]=1)=[CH:8][C:3]([CH3:2])=[CH:4][CH:5]=2

参加物

6

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 125044-Methylphenylhydrazine monohydrochloride

生成物 1

HCID 57435942N,5-Dimethyl-1H-indol-2-amine dihydrochloride

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒2 回

反応条件

温度
0 °C

実験手順

5 g of 1-(4-methylphenyl)hydrazine hydrochloride are dissolved in water and then triethylamine is added until the salt has been neutralized. Extraction is carried out with AcOEt and then the extract is evaporated to dryness. The precipitate formed is dissolved in 30 ml of ether and then a solution of 4.6 ml of acetic anhydride dissolved in 30 ml of ether is added dropwise. The mixture is stirred at 0° C. for 15 minutes and then the precipitate formed is filtered off to produce 3 g of the expected compound.

後処理

  1. extractionExtraction
  2. customthe extract is evaporated to dryness
  3. customThe precipitate formed
  4. additionis added dropwise
  5. customthe precipitate formed
  6. filtrationis filtered off

出典と根拠

ORDレコード
ord-1a490015bf8a457fa8d33947b9f5e475
出典データセット
uspto-grants-2008_06
特許番号
US07390818B2

関連ノート

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