化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Ethyl alpha-(hydroxymethylene)-4-methoxyphenylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethyl formate | HCID 8025 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Ethyl 4-methoxyphenylacetate | HCID 84174 | — |
| 生成物 | Ethyl alpha-(hydroxymethylene)-4-methoxyphenylacetate | HCID 67418551 | — |
反応手順
8.9 ml of ethyl p-methoxyphenylacetate are dissolved in 80 ml of ethyl formate. 4.6 g of 50% NaH are added portionwise and then the mixture is stirred at ambient temperature for 12 hours. It is poured onto a 1N HCl solution and then extraction is carried out with AcOEt. Purification is carried out by chromatography on a silica column eluted with an AcOEt/heptane (05/95; v/v) mixture to produce 4.0 g of the expected compound in the liquid form.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07390818B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-ed1232b3a26c47d492e3e6672f4cbf4a |
| 出典メモ | uspto-grants-2008_06 |