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Water → 4-Bromo-1-(bromomethyl)-2-chlorobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Azobisisobutyronitrile | HCID 6547 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 4-Bromo-2-chlorotoluene | HCID 2735554 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 4-Bromo-1-(bromomethyl)-2-chlorobenzene | HCID 21914486 | 55.3% |
反応手順
5.0 g of 2-chloro-4-bromotoluene are dissolved in 120 ml of CCl4. 4.3 g of NBS and 1.6 g of AIBN are added. The mixture is heated at reflux for 15 hours, water is added, the two phases are separated and then extraction is carried out with CH2Cl2. Purification is carried out by chromatography on a silica column eluted with petroleum ether. 3.8 g of liquid are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07390818B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-c412f9599aac43f2abfff64456467fa1 |
| 出典メモ | uspto-grants-2008_06 |