1-methyl-1H-pyrazole-3-carboxylic acid → 5-(2-Chloropyridin-3-yloxy)-2-(1-methyl-1H-pyrazol-3-yl)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

HRID 13320

反応式

HRID 13320 の反応式
[Cl:1][C:2]1[C:7]([O:8][C:9]2[C:23]([O:24][C:25]3[CH:26]=[N:27][C:28]([S:31]([CH2:34][CH3:35])(=[O:33])=[O:32])=[CH:29][CH:30]=3)=[CH:22][C:12]3[NH:13][C:14]([C:16]4[CH:21]=[CH:20]C=CN=4)=[N:15][C:11]=3[CH:10]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:36][N:37]1C=CC(C(O)=O)=[N:38]1>>[Cl:1][C:2]1[C:7]([O:8][C:9]2[C:23]([O:24][C:25]3[CH:26]=[N:27][C:28]([S:31]([CH2:34][CH3:35])(=[O:33])=[O:32])=[CH:29][CH:30]=3)=[CH:22][C:12]3[NH:13][C:14]([C:16]4[CH:21]=[CH:20][N:37]([CH3:36])[N:38]=4)=[N:15][C:11]=3[CH:10]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 5731761-methyl-1H-pyrazole-3-carboxylic acidHCID 112029605-(2-Chloropyridin-3-yloxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole

生成物 1

HCID 1356979705-(2-Chloropyridin-3-yloxy)-2-(1-methyl-1H-pyrazol-3-yl)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

実験手順

The entitled compound was obtained as a colorless solid in the same method as in Example 203 or in accordance with the method or by combining it with an ordinary method but using 4-(2-chloropyridin-3-yloxy)-5-(6-ethanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 242 and 1-methyl-1H-pyrazole-3-carboxylic acid.

後処理

  1. customThe entitled compound was obtained as a colorless solid in the same method as in Example 203 or in accordance with the method

出典と根拠

ORDレコード
ord-d7dcbb06ead24e0083353be24418b0ba
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

関連ノート

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