Homoserine lactone hydrobromide → 3-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)-amino-gamma-butyrolactone

HRID 133205

反応式

HRID 133205 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.Br.[NH2:19][CH:20]1[CH2:25][CH2:24][O:23][C:21]1=[O:22]>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([CH:25]2[CH2:24][O:23][C:21](=[O:22])[CH:20]2[NH2:19])=[O:17])[CH3:14])=[O:11])[CH:3]=[C:2]([F:1])[CH:7]=1

参加物

3

反応物 2

HCID 73508Homoserine lactone hydrobromideHCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid

生成物 1

HCID 865849673-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)-amino-gamma-butyrolactone

実験手順

Following General Procedure A above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and α-amino-γ-butyrolactone hydrobromide (Aldrich), the title compound was prepared as a solid having a melting point of 174-177° C. The reaction was monitored by tlc on silica gel (Rf=0.52 in 10% methanol/dichloromethane) and purification was by silica gel chromatography.

後処理

  1. customThe reaction was monitored by tlc on silica gel (Rf=0.52 in 10% methanol/dichloromethane) and purification

出典と根拠

ORDレコード
ord-3aca18a5c57c423aa71f27a9dc84e959
出典データセット
uspto-grants-2008_06
特許番号
US07390801B2

関連ノート

読み込み中…