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HRID 13322作成日：2026年10月26日

1-methyl-1H-pyrazole-3-carboxylic acid → 5-(2-Difluoromethoxy-pyridin-3-yloxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazole

https://huagongshe.com/reaction/13322

反応式

関与物質

役割名称HCID仕込み量
反応物1-methyl-1H-pyrazole-3-carboxylic acidHCID 573176—
反応物5-(2-Difluoromethoxy-pyridin-3-yloxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazoleHCID 11489567—
生成物5-(2-Difluoromethoxy-pyridin-3-yloxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazoleHCID 135697962—

反応手順

The entitled compound was obtained as a colorless solid in the same method as in Example 203 or in accordance with the method or by combining it with an ordinary method but using 4-(2-difluoromethoxy-pyridin-3-yloxy)-5-(6-ethanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 247 and 1-methyl-1H-pyrazole-3-carboxylic acid.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07728025B2
出典データセットuspto-grants-2010_06
ORD IDord-432da6b11ae548539f0b1457a1ae19c0
出典メモuspto-grants-2010_06