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3-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one → 3-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one | HCID 4434433 | — |
| 反応物 | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| 生成物 | 3-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one | HCID 10294459 | — |
反応手順
Following General Procedure A above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (General Procedure 6-B), the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.15 in 12% methanol/dichloromethane) and purification was by flash chromatography using 12% methanol/dichloromethane as the eluant.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07390801B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-aab835957cbe4552bd60b080c6d98579 |
| 出典メモ | uspto-grants-2008_06 |