関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 2-Fluorophenol | HCID 9707 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-(4-benzyloxy-5-fluoro-2-nitrophenyl)pyrazinecarboxamide | HCID 23145743 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(4-benzyloxy-5-(2-fluorophenoxy)-2-nitrophenyl)pyrazinecarboxamide | HCID 23145658 | — |
反応手順
0.54 ml of 2-fluorophenol and 2.53 g of potassium carbonate were added to a dimethylformamide (16 ml) solution of 2.14 g of N-(4-benzyloxy-5-fluoro-2-nitrophenyl)pyrazinecarboxamide, and the reaction liquid was stirred at 90° C. for 5 hours, and then water was added to it. The resulting deposit was taken out through filtration to obtain the entitled compound as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07728025B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-76da9412acef46d08b316ba9c7c4c87c |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
