2-Chloro-4-fluorobenzonitrile → n-(3-Chloro-4-cyanophenyl)alanine iso-butyl ester

HRID 133327

反応式

HRID 133327 の反応式
[Cl:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].Cl.[CH2:12]([O:16][C:17](=[O:21])[CH:18]([CH3:20])[NH2:19])[CH:13]([CH3:15])[CH3:14]>>[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH:19][C:8]1[CH:7]=[CH:6][C:3]([C:4]#[N:5])=[C:2]([Cl:1])[CH:9]=1)[CH:13]([CH3:15])[CH3:14]

参加物

3

反応物 2

HCID 1090002-Chloro-4-fluorobenzonitrileHCID 862001092-Methylpropyl 2-aminopropanoate hydrochloride

生成物 1

HCID 53791223n-(3-Chloro-4-cyanophenyl)alanine iso-butyl ester

実験手順

Following General Procedure AP above and using 2-chloro-4-fluorobenzonitrile (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example AA above), the title compound was prepared. The product was recovered by column chromatography on silica gel using 1:5 EtOAc/hexanes as the eluant.

後処理

  1. customThe product was recovered by column chromatography on silica gel using 1:5 EtOAc/hexanes as the eluant

出典と根拠

ORDレコード
ord-b417a860cdef47898322d20ece20b974
出典データセット
uspto-grants-2008_06
特許番号
US07390801B2

関連ノート

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