関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 反応物 | 1,2,3-Trifluoro-4-nitrobenzene | HCID 69871 | — |
| 反応物 | 2,6-Difluorophenol | HCID 94392 | — |
| 触媒 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 2,3-Difluoro-1-(2,6-difluoro-phenoxy)-4-nitro-benzene | HCID 23145286 | — |
反応手順
470 mg of 2,6-difluoro-phenol and 1.5 g of tetrabutylammonium bromide were added to an N-methylpyrrolidinone (13 ml) solution of 500 mg of 2,3,4-trifluoro-nitrobenzene, and the reaction liquid was stirred overnight at 130° C. The reaction liquid was diluted with ethyl acetate, washed with water and saturated saline in order, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=4/1) to obtain the entitled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07728025B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-11f1adab8b8e4535907931e7f083cac5 |
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| 出典メモ | uspto-grants-2010_06 |
|---|
