化工社化工社 化学情報印刷レポート · 研究参考用
Methyl pyruvate → N-(3,4-methylenedioxyphenyl)alanine Iso-butyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl pyruvate | HCID 11748 | — |
| 反応物 | 1,3-Benzodioxol-5-amine | HCID 84310 | — |
| 反応物 | N-(3,4-methylenedioxyphenyl)alanine methyl ester | HCID 54531586 | — |
| 溶媒 | Isobutanol | HCID 6560 | — |
| 生成物 | N-(3,4-methylenedioxyphenyl)alanine Iso-butyl Ester | HCID 54134455 | — |
反応手順
Following reductive amination General Procedure AA above and using 3,4-methylenedioxyaniline (Aldrich) and methyl pyruvate (Aldrich), N-(3,4-methylenedioxyphenyl)alanine methyl ester was prepared. The methyl ester was then transesterified following General Procedure AQ above and using iso butanol to provide the title compound as an oil. The reaction was monitored by silica gel dc (Rf=0.61 in 25% EtOAc/hexanes). Purification was by preparative plate chromatography with silica gel using 25% EtOAc/hexanes as the eluant.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07390801B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-12e04e799171427d96503c1f1f1c2440 |
| 出典メモ | uspto-grants-2008_06 |