Triethylamine → 3,5-Dichlorobenzyl methanesulfonate

HRID 133348

反応式

HRID 133348 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH2:5][OH:6].[CH3:11][S:12](Cl)(=[O:14])=[O:13].C(N(CC)CC)C>ClCCl>[CH3:11][S:12]([O:6][CH2:5][C:4]1[CH:3]=[C:2]([Cl:1])[CH:9]=[C:8]([Cl:10])[CH:7]=1)(=[O:14])=[O:13]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 432363,5-Dichlorobenzylic alcohol

生成物 1

HCID 224922533,5-Dichlorobenzyl methanesulfonate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 3.5 g of 3,5-dichlorobenzyl alcohol (Aldrich) in 75 mL of dichloromethane at 0° C. was added 1.8 mL of methane sulfonylchloride followed by 3.5 mL of triethylamine added dropwise. After 2 hours the solution was diluted to 150 mL with dichloromethane, washed with 3N HCl, saturated aqueous NaHCO3 dried with Na2SO4 and the solvents removed to yield the desired 3,5-dichlorobenzyl methanesulfonate as a yellow oil that was used without purification.

後処理

  1. additionadded dropwise
  2. washwashed with 3N HCl, saturated aqueous NaHCO3
  3. dry with materialdried with Na2SO4
  4. customthe solvents removed

出典と根拠

ORDレコード
ord-82ce7505cc384f4c9ec0c6e9a0874efc
出典データセット
uspto-grants-2008_06
特許番号
US07390801B2

関連ノート

読み込み中…