化工社化工社 化学情報印刷レポート · 研究参考用
Cyclohexaneacetic acid → N-(cyclohexyIacetyl)-L-alanine iso-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclohexaneacetic acid | HCID 21363 | — |
| 反応物 | 2-Methylpropyl (2S)-2-aminopropanoate hydrochloride | HCID 86584981 | — |
| 生成物 | N-(cyclohexyIacetyl)-L-alanine iso-butyl ester | HCID 54223838 | — |
反応手順
Following General Procedure BB above, and using cyclohexylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 92° C.-93° C. The reaction was monitored by tlc on silica gel (Rf=0.39 in 1:3 EtOAc:hexane) and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07390801B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-9894bab6b6cf48b18fd67724d538da7f |
| 出典メモ | uspto-grants-2008_06 |