L-Alanine ethyl ester → N-[(2-phenyl)-2-fluoroacetyl]alanine Ethyl Ester

HRID 133398

反応式

HRID 133398 の反応式
[F:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([OH:5])=O.[CH2:12]([O:14][C:15](=[O:19])[C@H:16]([CH3:18])[NH2:17])[CH3:13]>>[CH2:12]([O:14][C:15](=[O:19])[C@H:16]([CH3:18])[NH:17][C:3](=[O:5])[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[F:1])[CH3:13]

参加物

3

反応物 2

HCID 76507L-Alanine ethyl esterHCID 102649Fluorophenylacetic acid

生成物 1

HCID 22894970N-[(2-phenyl)-2-fluoroacetyl]alanine Ethyl Ester

実験手順

Following General Procedure BF above, and using α-fluorophenyl acetic acid (Aldrich) and alanine ethyl ester (Aldrich), the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.75 in 1:1 EtOAc:hexane) and purification was by chromatography on silica gel using 1:2 ethyl acetate/hexanes as the eluent.

後処理

  1. customThe reaction was monitored by tlc on silica gel (Rf=0.75 in 1:1 EtOAc:hexane) and purification

出典と根拠

ORDレコード
ord-8518db2c4b76423687970c4395dbf419
出典データセット
uspto-grants-2008_06
特許番号
US07390801B2

関連ノート

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