3-Bromopyridine → 4-(4-Phenylpiperidin-1-yl)pyridine
反応式
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>CC1=CC(C)=[O]->[Ni]2([O]1)[O]C(C)=CC(C)=[O]->2.CS(C)=O.C[Si](C)(C)[O-].O=C(N[C@@H]1CCCC[C@H]1NC(=O)c1ccccn1)c1ccccn1.[Na+]>c1ccc(C2CCN(c3cccnc3)CC2)cc1参加物
9
反応物 2
生成物 3
試薬・触媒・溶媒 4
反応条件
- 温度
- 60 °C
後処理
- customThe foil sealing tape was removed from the plate.
- addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
- filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 相を保持
- aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.
出典と根拠
- ORDレコード
- ord-ac39f4dcfb0840299333e820145f3a9d
- 出典データセット
- High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
- 元リンク
- 出典を表示
反応ノート
読み込み中…