Prolinamide, D- → (2R)-1-(6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidine-2-carboxamide

HRID 13367

反応式

HRID 13367 の反応式
C(OC(C1C=CC=CC=1O[C:9]1[C:23]([O:24][C:25]2[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][CH:26]=2)=[CH:22][C:12]2[NH:13][C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[N:15][C:11]=2[CH:10]=1)=O)C.[NH:39]1[CH2:46][CH2:45][CH2:44][C@@H:40]1[C:41]([NH2:43])=[O:42]>>[CH3:34][S:31]([C:28]1[CH:29]=[CH:30][C:25]([O:24][C:23]2[C:9]([N:39]3[CH2:46][CH2:45][CH2:44][C@@H:40]3[C:41]([NH2:43])=[O:42])=[CH:10][C:11]3[NH:15][C:14]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=4)=[N:13][C:12]=3[CH:22]=2)=[CH:26][CH:27]=1)(=[O:32])=[O:33]

参加物

3

反応物 2

HCID 447554Prolinamide, D-HCID 231451405-(2-Ethoxycarbonyl-phenoxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazole

生成物 1

HCID 67482442(2R)-1-(6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidine-2-carboxamide

実験手順

The entitled compound was obtained as a pale yellow solid in the same method as in Example 15 or in accordance with the method or by combining it with an ordinary method but using 5-fluoro-4-(4-methanesulfonyl-phenoxy)-2-nitro-phenylamine obtained in Example 14, and D-prolinamide.

後処理

  1. customThe entitled compound was obtained as a pale yellow solid in the same method as in Example 15 or in accordance with the method

出典と根拠

ORDレコード
ord-427cd56a08444ca2afe464402f5af879
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

関連ノート

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