Water → n-(2-Fluoro-4-hydroxyphenyl)acetamide

HRID 133732

反応式

HRID 133732 の反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][C:10]=1[F:16].O>C(O)(=O)C>[F:16][C:10]1[CH:11]=[C:12]([OH:15])[CH:13]=[CH:14][C:9]=1[NH:8][C:5](=[O:7])[CH3:6]

参加物

5

反応物 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 27359194-Amino-3-fluorophenol

生成物 1

HCID 190616n-(2-Fluoro-4-hydroxyphenyl)acetamide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Acetic anhydride (1.3 ml, 13.8 mmol) was added dropwise to a solution of 4-amino-3-fluorophenol (1.0 g, 7.9 mmol) in acetic acid (25 ml) at room temperature. The reaction mixture was stirred at room temperature for 2 h and water (2 ml) was added and the stirring was continued for 30 minutes at room temperature. The mixture was evaporated to dryness in vacuo. The yield of the crude product was 1.3 g (100%) and it was used without further purification.

後処理

  1. waitthe stirring was continued for 30 minutes at room temperature
  2. customThe mixture was evaporated to dryness in vacuo
  3. customwas used without further purification

出典と根拠

ORDレコード
ord-87286c2ade0143448a517e8f0fd7426b
出典データセット
uspto-grants-2008_06
特許番号
US07390923B2

関連ノート

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