2,3-Difluorobenzonitrile → 5-(2-Fluoro-6-cyanophenoxy)-2-pyridin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

HRID 13375ノート

反応式

HRID 13375 の反応式
[OH:1][C:2]1[C:16]([O:17][C:18]2[CH:19]=[N:20][C:21]([S:24]([CH2:27][CH3:28])(=[O:26])=[O:25])=[CH:22][CH:23]=2)=[CH:15][C:5]2[NH:6][C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=3)=[N:8][C:4]=2[CH:3]=1.[F:29][C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([C:36]#[N:37])[C:31]=1F>>[F:29][C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([C:36]#[N:37])[C:31]=1[O:1][C:2]1[C:16]([O:17][C:18]2[CH:19]=[N:20][C:21]([S:24]([CH2:27][CH3:28])(=[O:25])=[O:26])=[CH:22][CH:23]=2)=[CH:15][C:5]2[NH:6][C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=3)=[N:8][C:4]=2[CH:3]=1

参加物

3

反応物 2

HCID 889352,3-DifluorobenzonitrileHCID 178477648HCID 178477648、化合物

生成物 1

HCID 113182745-(2-Fluoro-6-cyanophenoxy)-2-pyridin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

実験手順

The entitled compound was obtained as a pale green solid in the same method as in Example 251 or in accordance with the method or by combining it with an ordinary method but using 5-hydroxy-2-pyridin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole obtained in Example 397 and 1,2-difluoro-3-cyano-benzene.

後処理

  1. customThe entitled compound was obtained as a pale green solid in the same method as in Example 251 or in accordance with the method

出典と根拠

ORDレコード
ord-95406735296e4bf7a458cd7b46629edf
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

反応ノート

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