2,3-Difluorobenzonitrile → 3-Fluoro-4-(2-fluoro-6-cyano-phenoxy)-phenylamine

HRID 13376ノート

反応式

HRID 13376 の反応式
[F:1][C:2]1[CH:3]=[C:4]([NH:9]C(=O)OC(C)(C)C)[CH:5]=[CH:6][C:7]=1[OH:8].[F:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]#[N:25])[C:19]=1F>>[F:1][C:2]1[CH:3]=[C:4]([NH2:9])[CH:5]=[CH:6][C:7]=1[O:8][C:19]1[C:20]([C:24]#[N:25])=[CH:21][CH:22]=[CH:23][C:18]=1[F:17]

参加物

3

反応物 2

HCID 889352,3-DifluorobenzonitrileHCID 11708410tert-Butyl (3-Fluoro-4-hydroxyphenyl)carbamate

生成物 1

HCID 231455073-Fluoro-4-(2-fluoro-6-cyano-phenoxy)-phenylamine

実験手順

The entitled compound was obtained in the same method as in Example 221 (step 1) or in accordance with the method or by combining it with an ordinary method but using tert-butyl (3-fluoro-4-hydroxy-phenyl)-carbamate obtained in Example 196 (step 1) and 1,2-difluoro-3-cyano-benzene.

後処理

  1. customThe entitled compound was obtained in the same method as in Example 221 (step 1) or in accordance with the method

出典と根拠

ORDレコード
ord-414d8a4d43ff49a59592db1cbfed2ad3
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

反応ノート

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