Hydrochloric Acid → 4-(3-Chloropropyl)phenol
反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10]O)=[CH:4][CH:3]=1.[ClH:12]>O>[Cl:12][CH2:10][CH2:9][CH2:8][C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=1参加物
4
実験手順
3-(4-Hydroxyphenyl)-1-propanol (0.97 g, 0.006374 mol) and concentrated HCl (20 ml) were heated at 100° C. for 14 h. After being cooled, the reaction mixture was poured into water and extracted with ethyl acetate. The extracts were washed with water, dried and concentrated in vacuo to give a raw product. Purification by flash chromatography (heptane/ethyl acetate 9:1) gave a pure product (0.98 g, 90%).
後処理
- temperatureAfter being cooled
- extractionextracted with ethyl acetate
- washThe extracts were washed with water
- customdried
- concentrationconcentrated in vacuo
- customto give a raw product
- customPurification by flash chromatography (heptane/ethyl acetate 9:1)
出典と根拠
- ORDレコード
- ord-5ddef234d35e48a58ec24166d96c46f4
- 出典データセット
- uspto-grants-2008_06
- 特許番号
- US07390923B2
反応ノート
読み込み中…