2,3-Difluorobenzonitrile → 4-(2-cyano-6-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole

HRID 13379

反応式

HRID 13379 の反応式
[OH:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)[NH:7][C:6]=2[CH:5]=[C:4]([O:17][C:18]2[CH:19]=[N:20][C:21]([S:24]([CH2:27][CH3:28])(=[O:26])=[O:25])=[CH:22][CH:23]=2)[CH:3]=1.F[C:30]1[C:37]([F:38])=[CH:36][CH:35]=[CH:34][C:31]=1[C:32]#[N:33]>>[C:32]([C:31]1[CH:34]=[CH:35][CH:36]=[C:37]([F:38])[C:30]=1[O:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)[NH:7][C:6]=2[CH:5]=[C:4]([O:17][C:18]2[CH:19]=[N:20][C:21]([S:24]([CH2:27][CH3:28])(=[O:25])=[O:26])=[CH:22][CH:23]=2)[CH:3]=1)#[N:33]

参加物

3

実験手順

The entitled compound was obtained in the same method as in Example 251 (step 2) or in accordance with the method or by combining it with an ordinary method but using 4-hydroxy-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole and 2,3-difluorobenzonitrile.

後処理

  1. customThe entitled compound was obtained in the same method as in Example 251 (step 2) or in accordance with the method

出典と根拠

ORDレコード
ord-2d5045f790684d51b8cb06ed1862fd64
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

関連ノート

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