4-(2-Cyano-6-fluoro-phenoxy)-6-(6-methanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole → HCID 23145718、化合物
反応式
C([C:3]1[CH:35]=[CH:34][CH:33]=[C:32]([F:36])[C:4]=1[O:5][C:6]1[C:14]2[N:13]=[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[NH:11][C:10]=2[CH:9]=[C:8]([O:21][C:22]2[CH:23]=[N:24][C:25]([S:28]([CH3:31])(=[O:30])=[O:29])=[CH:26][CH:27]=2)[CH:7]=1)#N.FC1C(F)=CC=C[C:39]=1[S:45](C)(=[O:47])=[O:46]>>[F:36][C:32]1[CH:33]=[CH:34][CH:35]=[C:3]([S:45]([CH3:39])(=[O:47])=[O:46])[C:4]=1[O:5][C:6]1[C:14]2[N:13]=[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[NH:11][C:10]=2[CH:9]=[C:8]([O:21][C:22]2[CH:23]=[N:24][C:25]([S:28]([CH3:31])(=[O:30])=[O:29])=[CH:26][CH:27]=2)[CH:7]=1参加物
3
実験手順
The entitled compound was obtained as a pale yellow solid in the same method as in Example 438 (step 2) or in accordance with the method or by combining it with an ordinary method but using 4-hydroxy-6-(6-methanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole obtained in Example 447 and 2,3-difluoro-methanesulfonylbenzene.
後処理
- customThe entitled compound was obtained as a pale yellow solid in the same method as in Example 438 (step 2) or in accordance with the method