Imidazole → 3-(tert-butyldimethylsilyloxy)dihydrofuran-2(3H)-one

HRID 13382

反応式

HRID 13382 の反応式
N1C=CN=C1.[Si:6](Cl)([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7].CN(C)C=O.[OH:19][CH:20]1[CH2:24][CH2:23][O:22][C:21]1=[O:25]>C(OCC)(=O)C>[Si:6]([O:19][CH:20]1[CH2:24][CH2:23][O:22][C:21]1=[O:25])([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7]

参加物

6

反応物 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 28928tert-Butyldimethylsilyl chlorideHCID 545831alpha-Hydroxy-gamma-butyrolactone

生成物 1

HCID 50462413-(tert-butyldimethylsilyloxy)dihydrofuran-2(3H)-one

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

9.0 g of imidazole and 15.9 g of t-butyldimethylsilyl chloride were added in order to a dimethylformamide (180 ml) solution of 9.0 g of 3-hydroxydihydrofuran-2-(3H)-one, and the reaction liquid was stirred for 1 hour at room temperature. The reaction liquid was diluted with ethyl acetate, washed with water, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=5/1) to obtain the entitled compound as a colorless oily substance.

後処理

  1. customthe reaction liquid
  2. customThe reaction liquid
  3. washwashed with water
  4. dry with materialdried with anhydrous sodium sulfate
  5. customThe solvent was evaporated away under reduced pressure
  6. customthe resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=5/1)
  7. customto obtain the entitled compound as a colorless oily substance

出典と根拠

ORDレコード
ord-231380418bd64564bb18d212d111574c
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

関連ノート

読み込み中…