1,4-Dioxane hydrochloride → (3-Fluoro-4-pyrrolidin-2-ylphenyl)amine dihydrochloride
反応式
[ClH:1].O1CCOCC1.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[CH2:19][CH2:18][CH2:17][N:16]2C(OC(C)(C)C)=O)=[C:11]([F:27])[CH:10]=1>C(OCC)(=O)C.CO>[ClH:1].[ClH:1].[F:27][C:11]1[CH:10]=[C:9]([NH2:8])[CH:14]=[CH:13][C:12]=1[CH:15]1[CH2:19][CH2:18][CH2:17][NH:16]1参加物
5
実験手順
100 ml of 4 N hydrochloric acid-dioxane solution was added to a solution of 19 g of t-butyl 2-(4-amino-2-fluoro-phenyl)-pyrrolidine-1-carboxylate obtained in Example 338 (step 2) in a mixture of 50 ml of ethyl acetate and 50 ml of methanol, with cooling with ice, and the reaction liquid was stirred overnight at room temperature. The solvent was evaporated away under educed pressure to obtain the entitled compound as a white solid.
後処理
- temperaturewith cooling with ice
- customthe reaction liquid
- customThe solvent was evaporated away under educed pressure
出典と根拠
- ORDレコード
- ord-b7e1e372bc744877a5daed6594f78177
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07728025B2
反応ノート
読み込み中…