1,4-Dioxane hydrochloride → N-(3-fluoro-4-pyrrolidin-2-ylphenyl)pyrazine-2-carboxamide dihydrochloride

HRID 13411ノート

反応式

HRID 13411 の反応式
[ClH:1].O1CCOCC1.[F:8][C:9]1[CH:14]=[C:13]([NH:15][C:16]([C:18]2[CH:23]=[N:22][CH:21]=[CH:20][N:19]=2)=[O:17])[CH:12]=[CH:11][C:10]=1[CH:24]1[CH2:28][CH2:27][CH2:26][N:25]1C(OC(C)(C)C)=O>CO>[ClH:1].[ClH:1].[F:8][C:9]1[CH:14]=[C:13]([NH:15][C:16]([C:18]2[CH:23]=[N:22][CH:21]=[CH:20][N:19]=2)=[O:17])[CH:12]=[CH:11][C:10]=1[CH:24]1[CH2:28][CH2:27][CH2:26][NH:25]1

参加物

4

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 23145269t-Butyl 2-(2-fluoro-4-((pyrazin-2-ylcarbonyl)amino)phenyl)pyrrolidine-1-carboxylate

生成物 1

HCID 23145221N-(3-fluoro-4-pyrrolidin-2-ylphenyl)pyrazine-2-carboxamide dihydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

50 ml of 4 N hydrochloric acid-dioxane solution was added to a methanol (50 ml) solution of 4.4 g of t-butyl 2-(2-fluoro-4-((pyrazin-2-ylcarbonyl)amino)phenyl)pyrrolidine-1-carboxylate, and the reaction liquid was stirred at room temperature for 1 hour. The solvent was evaporated away under reduced pressure to obtain the entitled compound as a yellow solid.

後処理

  1. customthe reaction liquid
  2. customThe solvent was evaporated away under reduced pressure

出典と根拠

ORDレコード
ord-9fc5ac2acc374720aa192c73f83054b3
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

反応ノート

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