化工社化工社 化学情報印刷レポート · 研究参考用
4-Bromoaniline → N-(4-bromophenyl)-5-methoxy-1,3-benzothiazol-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromoaniline | HCID 7807 | — |
| 反応物 | 2-Bromo-5-methoxybenzothiazole | HCID 22040525 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | N-(4-bromophenyl)-5-methoxy-1,3-benzothiazol-2-amine | HCID 7489958 | — |
反応手順
The mixture containing 2-bromo-5-methoxybenzthiazole (1 eq), 4-Bromoaniline (2 eq) and disopropylethylamine was subjected to microwave in NMP at 220° C. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave the desired product. MS: MH+=335
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728010B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-02426daa880b45148c58ba484bdb01f2 |
| 出典メモ | uspto-grants-2010_06 |