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4-Bromoaniline → (4-Bromophenyl)(5-methoxybenzoxazol-2-yl)amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromoaniline | HCID 7807 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-Chloro-5-methoxy-1,3-benzoxazole | HCID 11819712 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (4-Bromophenyl)(5-methoxybenzoxazol-2-yl)amine | HCID 22040817 | — |
反応手順
The mixture containing 2-chloro-5-methoxybenzoxazole (1 eq), 4-bromoaniline (2 eq) and diisopropylethylamine was refluxed in dimethylformamide. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave (4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine. MS: MH+=318
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728010B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-9bac4797f8dc4d1cae695a5979e23f2d |
| 出典メモ | uspto-grants-2010_06 |