Hydrogen chloride-ethyl acetate → HCID 178418232、化合物

HRID 1346

反応式

HRID 1346 の反応式
[CH3:1][C:2]1[NH:3][C:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[N:8]([C:15]([C:17]3[CH:37]=[CH:36][C:20]([NH:21][C:22](=[O:35])[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[CH:19][CH:18]=3)=[O:16])[CH2:7][CH2:6][C:5]=2[N:38]=1.[ClH:39].C(OCC)(=O)C>C(O)C>[ClH:39].[CH3:1][C:2]1[NH:3][C:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[N:8]([C:15]([C:17]3[CH:37]=[CH:36][C:20]([NH:21][C:22](=[O:35])[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=4)=[CH:19][CH:18]=3)=[O:16])[CH2:7][CH2:6][C:5]=2[N:38]=1

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178418305HCID 178418305、化合物

生成物 1

HCID 178418232HCID 178418232、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4'-[(2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepin-6-yl)carbonyl]-2-phenylbenzanilide was dissolved in 5 ml of ethyl alcohol, the resulting solution was mixed with 0.19 ml of 4N hydrochloric acid-ethyl acetate and cooled on an ice bath and then the thus precipitated crystals were collected by filtration and washed with a small volume of ethyl alcohol to obtain 220 mg of 4'-[(2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepin-6-yl)carbonyl]-2-phenylbenzanilide hydrochloride (Example 18(2)).

後処理

  1. temperaturecooled on an ice bath
  2. filtrationthe thus precipitated crystals were collected by filtration
  3. washwashed with a small volume of ethyl alcohol

出典と根拠

ORDレコード
ord-63cce50ac648477a9245c0dedfc173bd
出典データセット
uspto-grants-1998_03
特許番号
US05723606

関連ノート

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